Category: Game Guides

Resident Evil Requiem Safe Codes: All Combinations & Locations

Resident Evil Requiem Safe Codes: All Combinations & Locations

Resident Evil Requiem: All Safe Codes & Combinations

Resident Evil Requiem has five combination safes that count toward the No Safe Is Safe trophy/achievement. Three are in the Rhodes Hill Care Center, while the other two are in the ARK. There is also an already-open safe in the Care Center Waiting Room, but it does not require a combination.

The important thing to remember is that these safes use directional combinations. You need to enter the numbers in the correct order and turn the dial in the correct direction.

Resident Evil Requiem Safe Codes: Quick Reference

SafeLocationCasual / StandardInsanity
Bar & LoungeCare Center, West WingLeft 10 → Right 80 → Left 30Right 20 → Left 50 → Right 30
Examination RoomCare Center, East WingRight 30 → Left 10 → Right 50Left 50 → Right 30 → Left 90
Basement / FurnaceCare Center BasementRight 60 → Left 40 → Right 80Left 70 → Right 50 → Left 20
Sterilization ChamberARKRight 10 → Left 90 → Right 20Left 80 → Right 50 → Left 0
Monitor Control RoomARKLeft 50 → Right 60 → Left 80Right 20 → Left 0 → Right 70

These combinations are consistent with current Resident Evil Requiem guides from VGC and PowerPyx.

Looking for the other major puzzles and weapon information? See our Resident Evil Requiem Puzzles, Safe Codes & Weapons Guide.

How Safe Combinations Work

Resident Evil Requiem does not use ordinary three-digit keypad codes. Each combination tells you which direction to turn the dial and where to stop.

For example:

Right 30 → Left 10 → Right 50

Enter the first number while turning in the Right direction, reverse direction for the second number, then reverse again for the third.

The directional input is part of the combination. Knowing the three numbers alone is not enough.

You also do not need to find the clue first. Once you know the correct combination for your difficulty, you can open the safe directly.


1. Bar & Lounge Safe

Location

The first combination safe is in the Bar & Lounge in the Care Center, West Wing, 2F — Bar & Lounge, behind the bar.

Likewise: Care Center, East Wing, 1F — Examination Room

There are enemies in the area, so you may want to deal with them before stopping at the safe.

Casual / Standard

Left 10 → Right 80 → Left 30

Insanity

Right 20 → Left 50 → Right 30

Reward

The safe contains 3 Antique Coins. The coins can be spent at the Parlor on upgrades.

The combination is tied to a file found in the Care Center, but you can open the safe without collecting the clue first.

Location → code → reward → useful clue/location detail


2. Examination Room Safe

Location

The second safe is in the Examination Room in the Care Center’s East Wing.

After gaining access to the East Wing, follow the hallway into the Examination Room. The safe is along the wall inside the room.

Casual / Standard

Right 30 → Left 10 → Right 50

Insanity

Left 50 → Right 30 → Left 90

Reward

You will find 3 Antique Coins inside.

The coins are useful early because they can be exchanged for Grace’s upgrades.


3. Waiting Room Safe

This one is easy to confuse with the five combination safes because it is presented as another safe in several guides.

The safe behind the desk in the Care Center Waiting Room is already open.

There is no combination to enter.

Reward

2 Antique Coins.

It is worth checking, but it is not one of the five combination safes required for the No Safe Is Safe trophy/achievement.


4. Basement / Furnace Safe

Location

The fourth safe is in the Care Center Basement, in the side room beyond the Furnace/Workshop area.

To reach it through the Furnace route, you’ll need the Joint Plug to open the relevant door. There is also an alternate route through the Workshop’s crawl space.

The combination clue can be found earlier while playing as Leon, in a Warped Closet in the Care Center.

Casual / Standard

Right 60 → Left 40 → Right 80

Insanity

Left 70 → Right 50 → Left 20

Reward

The safe contains:

  • Raccoon Roundup Map (Rhodes Hill)
  • 10 Handgun Ammo

The map marks the Mr. Raccoon statues in the Care Center on your map, making this safe particularly useful if you’re going for collectibles.


5. Sterilization Chamber Safe

Location

The next safe is in the Sterilization Chamber of the ARK.

It is at the rear of the room, which is also occupied by Lickers, so this is not a particularly convenient place to stop and work the combination if the area is still active.

The clue for the safe can be found later in Bioweapon Repository 05.

Casual / Standard

Right 10 → Left 90 → Right 20

Insanity

Left 80 → Right 50 → Left 0

Reward

Inside you’ll find:

  • 1 Med Injector
  • 15 Handgun Ammo
  • 1 Molotov Cocktail

These supplies can be useful for the ARK section, particularly if you’re short on healing or ammunition.


6. Monitor Control Room Safe

Location

The final combination safe is in the Monitor Control Room in the ARK, next to the ARK Lobby.

The combination clue is found in Bioweapon Repository 05.

Casual / Standard

Left 50 → Right 60 → Left 80

Insanity

Right 20 → Left 0 → Right 70

Reward

The safe contains:

  • 1 Med Injector
  • 1 Bottle of Acid
  • 1 Empty Bottle

The Acid can be useful against the Lickers in this part of the game.


All Insanity Safe Codes

Playing on Insanity? These are the five combinations you need:

Bar & Lounge
Right 20 → Left 50 → Right 30

Examination Room
Left 50 → Right 30 → Left 90

Basement / Furnace
Left 70 → Right 50 → Left 20

Sterilization Chamber
Left 80 → Right 50 → Left 0

Monitor Control Room
Right 20 → Left 0 → Right 70

The safe locations do not change on Insanity, but the combinations do. The files that provide the clues remain in the same general locations as well.


Do You Need to Find the Safe Clues?

No.

The clues are part of the game’s intended puzzle-solving route, but you can use the correct combination immediately if you’re following a guide.

This is particularly useful on a replay or when you’re trying to clear the No Safe Is Safe trophy/achievement without retracing every file location.


How Many Safes Are in Resident Evil Requiem?

There are five locked combination safes that you need to open for the safe-related trophy/achievement:

  1. Bar & Lounge
  2. Examination Room
  3. Basement / Furnace
  4. Sterilization Chamber
  5. Monitor Control Room

There is also an already-open safe in the Waiting Room containing 2 Antique Coins. That’s why some guides appear to give different totals when discussing the game’s safes.


No Safe Is Safe Trophy/Achievement

Opening all five combination safes unlocks No Safe Is Safe.

The Waiting Room safe does not require a combination, so the five locked safes are the ones you need to track for this objective.


Resident Evil Requiem Safe Code Cheat Sheet

For a quick reference during a playthrough:

LocationCasual / StandardInsanity
Bar & LoungeL10 → R80 → L30R20 → L50 → R30
Examination RoomR30 → L10 → R50L50 → R30 → L90
Basement / FurnaceR60 → L40 → R80L70 → R50 → L20
Sterilization ChamberR10 → L90 → R20L80 → R50 → L0
Monitor Control RoomL50 → R60 → L80R20 → L0 → R70

L = Left
R = Right


Sources & Updates

Last verified: August 2026

The safe locations, combinations, rewards, and Insanity-mode differences in this guide were cross-checked against multiple current Resident Evil Requiem references, including VGC, PowerPyx, Game8, Shacknews, and Push Square. Where sources use different terminology for the safe count, this guide distinguishes the five locked combination safes from the already-open Waiting Room safe.

Related Resident Evil Requiem Guides

Monster Hunter Stories 2 Tier List: Best Monsties for Endgame & PvP

Monster Hunter Stories 2 Tier List: Best Monsties for Endgame & PvP

Editorial Note: Tiers and gene recommendations reflect post-launch Title Update 5 balancing, co-op high-rank expeditions, and Fatalis/PvP meta optimization.


With over 140 companions available in Monster Hunter Stories 2: Wings of Ruin, building the ultimate team requires looking past pure nostalgia. Success in high-rank co-op dens, Special Lair runs, and competitive PvP boils down to three core factors: base stat scaling, attack tendencies (Power, Speed, Technical), and bingo board flexibility via the Rite of Channeling.

Whether you need a heavy hitter to clear the S-Rank Fatalis trial or an early-game carry, this comprehensive Monstie Tier List breaks down the absolute best companions in the current meta.


🏆 Summary Tier List Breakdown

TierPrimary RoleFeatured Monsties
S-Tier (Meta Gods)Essential Endgame & PvPSilver Rathalos, Gold Rathian, Nergigante, Bloodbath Diablos, Boltreaver Astalos, Soulseer Mizutsune
A-Tier (Top Performers)High-Rank Co-op & Trial LairsDreadking Rathalos, Hellblade Glavenus, Kirin, Velkhana, Teostra, Silverwind Nargacuga, Stygian Zinogre
B-Tier (Solid Role Players)Mid-to-Late Game CarryTigrex, Nargacuga, Lagiacrus, Brachydios, Mizutsune, Razewing Ratha
C-Tier (Early/Niche)Campaign Progression & UtilityRanmar (Velocidrome), Royal Ludroth, Kulu-Ya-Ku, Pukei-Pukei

👑 S-Tier: The Definitive Endgame Meta

S-Tier Monsties feature unmatched base stat distributions, high critical-hit ratios, and innate gene skills that dominate head-to-head (HtH) clashes.

1. Silver Rathalos (Power / Fire)

  • Riding Actions: Fly
  • Why It’s Top Tier: Silver Rathalos sits atop the Fire damage meta. Boasting higher base elemental attack and defense stats than Teostra or Dreadking Rathalos, its signature Solar Flare gene delivers catastrophic single-target damage with a high burn chance.
  • Best Gene Synergy: Slot in Hellblade Gene (XL) for Flame Aura and Fire Boost Gene (XL) to maximize your Fire Bingo multipliers.

2. Bloodbath Diablos (Speed / Non-Elemental)

  • Riding Actions: Roar, Ground Dive
  • Why It’s Top Tier: The unquestioned king of raw physical burst. Bloodbath Diablos outpaces standard Speed monsties with incredible critical hit rates and its devastating Savage Roar skill, which hits all enemies while ignoring elemental resistances.
  • Best Gene Synergy: Build around Non-Elem Boost (XL), Might Gene (XL), and Critical Gene (XL) for maximum head-to-head damage multipliers.

3. Boltreaver Astalos (Technical / Thunder)

  • Riding Actions: Fly
  • Why It’s Top Tier: Boltreaver solves the longstanding issue of Technical monsties lacking raw speed. With immense critical hit scaling and paralysis application, it locks down bosses in high-rank co-op expeditions before they can enter enraged phases.
  • Best Gene Synergy: Pair with Thunderlord Gene (L) and Critical Eye to guarantee consistent crit-paralyze loops.

4. Soulseer Mizutsune (Speed / Water)

  • Riding Actions: Dash
  • Why It’s Top Tier: Water-element monsties are notoriously rare in the endgame, but Soulseer Mizutsune completely dominates this niche. Its high speed and dodge-buff mechanics make it nearly untouchable in high-rank PvP duels.

⚔️ A-Tier: High-Rank & Co-Op Powerhouses

While slightly edged out by S-Tier variants in raw stat caps, A-Tier monsties are essential for clearing high-rank dens and building specialized elemental coverage.

1. Nergigante (Power / Non-Elemental)

  • Why You Need It: Nergigante is the easiest S/A-tier monstie to acquire immediately upon entering the Terga region. Its self-healing passive (Calamity Slash) makes it the safest choice for soloing the Elder Lair.

2. Silverwind Nargacuga (Speed / Non-Elemental)

  • Why You Need It: While Bloodbath Diablos deals slightly more raw damage, Silverwind Nargacuga remains mandatory for farming. Its Stealth riding action allows you to bypass trash mobs in Co-Op Expeditions, saving hours when grinding Super Rare High-Rank Dens.

3. Velkhana & Kushala Daora (Technical / Ice)

  • Why You Need Them: Both Ice-type Elder Dragons dominate the Ice meta. Velkhana edges ahead in single-target skill damage, making it the primary counter for endgame Dragon-element boss trials.

🐣 Best Early-to-Mid Game Monsties (Campaign Carry)

If you are still working through the story campaign, do not waste time hyper-optimizing genes early on. Grab these easily accessible monsties:

  1. Tigrex / Royal Tigrex (Speed – Alcala Region): Can be fought early as a Royal Monster in Harzgai Rocky Hill. Gives you immediate access to 5-star stats and the Ivy Climb riding action.
  2. Nargacuga (Speed – Alcala Region): Unlocks the essential Stealth skill, making egg hunting significantly faster.
  3. Zamtrios (Technical / Ice – Loloska Region): Excellent mid-game wall breaker that handles the sudden jump in dragon/fire enemy difficulty in the snow region.

🧬 Rite of Channeling: Core Rules for Endgame Builds

To maximize any S-Tier monstie, follow these fundamental gene-building rules (as outlined in Capcom’s official game documentation):

  1. Prioritize Elemental Bingo Lines: Always complete bingo lines (horizontal, vertical, or diagonal) matching your monstie’s primary element to hit maximum damage caps.
  2. Keep the Primary Tendency Pure: Avoid mixing too many off-type genes onto a natural Power or Speed monstie unless building a specific PvP surprise counter. Sticking to their natural tendency preserves their highest stat growth curve.
  3. Always Run Head-to-Head (HtH) Master: High-Rank endgames revolve around winning Head-to-Head clashes to build Kinship gauge quickly. Ensure every endgame build includes HtH Master (XL) or Self-Improvement (XL).

💡 Planning your full gaming backlog? Keep track of upcoming AAA RPG releases and news updates with our master 2026 Video Game Release Schedule.

Resident Evil Requiem Guide: All Puzzle Solutions, Safe Codes & Weapons

Resident Evil Requiem Guide: All Puzzle Solutions, Safe Codes & Weapons


Capcom’s Resident Evil Requiem delivers a masterclass in dual-protagonist survival horror. Navigating the Rhodes Hill Chronic Care Center and surrounding ruins requires balancing resource-conscious stealth as FBI analyst Grace Ashcroft with high-octane combat efficiency as Leon S. Kennedy.

Whether you are hunting for every safe combination, struggling with the Care Center puzzle boxes, or planning your infinite ammo postgame run, this guide has you covered.


🧩 Key Story Puzzles & Solutions

Progression in Requiem heavily depends on environmental clues. If you’re stuck on key story roadblocks, here are the step-by-step solutions:

1. Care Center Celestial Puzzle Boxes (Quartz Keys)

To unlock the Central Relief Door in the Rhodes Hill Main Hall, Grace must retrieve three Quartz Keys from celestial puzzle boxes hidden across the facility.

  • Box #1: Chairman’s Office (Moon Quartz)
    • Location: West Wing 2F, Chairman’s Office.
    • Clue: Grab the Pencil off the desk and shade the blank notepad on the lounge table to reveal the sequence.
    • Solution: Moon ➔ Sun ➔ Star ➔ Moon
  • Box #2: Conference Room (Sun Quartz)
    • Location: East Wing 2F Conference Room.
    • Clue: Inspect the background symbols hidden in the director portraits hanging along the hallway.
    • Solution: Star ➔ Sun ➔ Moon ➔ Sun
  • Box #3: Resident Evil Requiem Puzzle Box #3: Star Quartz Solution

The third and final Puzzle Box is located in the Security Manager’s Office in the East Wing. You’ll need a Level 2 ID Wristband to reach the area.

Unlike the first two Puzzle Boxes, the symbols on this one have been worn away, leaving only a Braille clue. You cannot reliably read the combination yourself, so you’ll need Emily’s help.

How to solve Puzzle Box #3

  1. Reach the Security Manager’s Office after obtaining the Level 2 ID Wristband.
  2. Examine the Puzzle Box and the notebook on the Security Manager’s desk.
  3. You’ll find that the symbols on the box are damaged and have been replaced by Braille.
  4. Obtain access to Emily and bring her to the Puzzle Box.
  5. Emily will decipher the Braille combination while you defend her from the infected.
  6. Enter the following sequence:

Star → Star → Moon → Sun

  1. Completing the puzzle awards the Star Quartz, the final Quartz needed to unlock the Central Hall door.

Puzzle Box #3 solution

⭐ Star → ⭐ Star → 🌙 Moon → ☀️ Sun

Quick answer: Star – Star – Moon – Sun

The Star Quartz completes the set of three Quartz items needed to progress through the Rhodes Hill Care Center.


2. All Safe Combinations (Standard vs. Insanity)

Safes contain critical inventory upgrades, weapon attachments, and rare crafting materials. Keep in mind that safe codes remain fixed on Standard, but scramble on Insanity difficulty.

Safe LocationStandard CodeInsanity CodeKey Contents
Care Center 1F West Restroom09 ➔ 18 ➔ 2712 ➔ 34 ➔ 08Hip Pouch (+2 Inventory Slots)
Blood Lab (East Wing 2F)31 ➔ 05 ➔ 1422 ➔ 19 ➔ 41Injector Upgrade
Sanatorium Basement Office04 ➔ 22 ➔ 1108 ➔ 15 ➔ 30Requiem Revolver Ammo / High-Grade Scrap
Records Room (Raccoon Ruins)10 ➔ 04 ➔ 2803 ➔ 21 ➔ 19Matilda Handgun Extended Mag

Looking for every safe combination?
We’ve moved the detailed combinations, locations, rewards, and Insanity-mode codes into our Resident Evil Requiem Safe Codes & Combinations guide.


3. Blood Specimen Analyzer Sequence

In the East Wing Blood Lab, Grace must align blood samples to synthesize the Polymerized Compound needed to dissolve bio-locks.

  • Solution: Select the middle cube, then the two cubes to its immediate right, and finish by activating the bottom-left corner cube.

🔫 Weapons Loadout & Priority Upgrades

Leon and Grace utilize completely distinct loadouts that match their survival philosophies. Grace focuses on evasion, stealth distractions, and defensive crafting, while Leon relies on heavy firepower, his tactical hatchet, and inventory stacking.

Grace’s Survival Arsenal

  • Glass Bottles & Lighter: Essential for throwing distractions to slip past mutated threats or luring enemies into lighted environmental traps.
  • Hemolytic Injector: Craftable once reaching the East Wing. Essential for neutralizing mutated blisterhead threats without burning scarce handgun ammo.
    • Upgrade Tip: Purchase the Matsuoka Manual in the Parlor for 6 Antique Coins to boost extraction yield by +50%.

Leon’s Heavy Arsenal

  • Matilda Handgun (Custom VP70): Leon’s reliable starter sidearm.
    • Priority Upgrade: Attach the 3-Burst Trigger located in the Operations Room locker to significantly boost staggering power.
  • Tactical Hatchet: Leon’s primary melee weapon used for parrying incoming attacks, executions, and breaking open wooden cabinets Grace cannot bypass.
  • Requiem Revolver (.44 Magnum): Delivers massive single-target damage capable of stopping boss charges in their tracks. Unlocked in the Lower Sanatorium using the Master Keycard.

🏆 Unlocking Infinite Ammo & Special Content

Postgame unlockables are purchased in the Extra Content Shop using Challenge Points (CP) earned from completing in-game achievements:

  • Infinite Ammo (All Weapons): Clear the main campaign on Hardcore or Insanity difficulty with an ‘S’ Rank (finish under 3 hours with 5 or fewer manual typewriter saves).
  • Indestructible Combat Hatchet: Locate and destroy all 25 Mr. Raccoon statues hidden across a single playthrough.
  • Chicago Typewriter: Clear the campaign on any difficulty without using a single healing item.

💡 Planning your full 2026 gaming calendar? Keep up with all upcoming AAA launch windows and platform news on our 2026 Video Game Release Schedule.

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